The substantiation of the choice of a gel former for developing the gel composition with hyaluronic acid and decametoxin

Topicality. Bedsores are an urgent problem of modern medicine both at the outpatient and inpatient stage. For treatment infected bedsores it is advisable to use drugs that have a complex effect focused on various parts pathological process. chronic wounds together with inhibition growth microorganisms drug must provide optimal conditions for granulation, reparative anti-inflammatory effect. Aim. To experimentally substantiate composition gel base hyaluronic acid decamethoxine. Materials methods. select structure-forming component in base, possibility using “Ultrez 10 NF” carbomer, “Aristoflex AVC” (copolymer acrylamidomethylpropanesulfonic vinyl pyrrolidone) from Clariant Surfactants company, “Structure XL” (hydropropylated corn starch) as gelling agent was studied. Organoleptic, physicochemical, structural mechanical parameters model samples were determined according methods State Pharmacopoeia Ukraine. The statistical processing results performed Statistica 6.0 program. Results discussion. choice taking into account study organoleptic, samples. experimental studies conducted allowed choose – concentration 1 %. It easily dispersed water does not require addition neutralizer. has been proven selected consumer, structural-mechanical, physicochemical properties. Conclusions. Based structural-mechanical decamethoxine substantiated.